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What is Biotin?
It is made up of extraordinary form, with two ring fused jointly through one of their sides. The two rings are ureido and thiophene moieties. Biotin is heterocyclic, S-comprising monocarboxylic acid. It is formed from two precursors, alanine and pimeloyl-CoA around three enzymes. 8-Amino-7-oxopelargonic acid synthase is a pyrodixal 5ᶦ-phosphate enzyme.
The pimeloyl-CoA, be able to developed by a qualified fatty acid pathway comprising a malonyl as the starter. 7 and 8 Diaminopelargonic acid or DAPA aminotransferase is unique in using S-adenosyl methionine or SAM as the NH₂ donor. Dethiobiotin synthethase catalyzes the establishment of the ureido ring through a DAPA carbamate started with ATP.
Biotin synthase reductively devides SAM into a deoxyadenosyl radical‒a primary radical created on dethiobiotin is trapped by the sulfur donor, which was form to be the iron-sulfur (Fe-S) center contained in the enzyme.
Also known as vitamin B7, vitamin H, or coenzyme R. It is a water-soluble vitamin that is usually categorized as a B-complex vitamin and can be synthesized only by molds, algae, yeast, bacteria, and some plant species. It took 40 years of studies before it was establish as a vitamin.
Biotin is vital to the growth of cells, the transmutation of fats and amino acids, and the formation of fatty acids, the building blocks of protein. It assists the body to convert Carbohydrates (food) into glucose, which is applied to generate energy.Pregnancy week by week
Biotin for hair growth
Even though there is a few studies support the effects of biotin on hair growth, it may have a significant role in the growth and maintenance of your lock and nails. Biotin intake can do a great help to stimulate new hair and nail growth. Even though you have a normal biotin levels, you can opt to take biotin supplement to stimulate to quicken your hair or nail growth.
There is direct relationship between Hair growth and biotin.
Biotin improves hair growth and prevents hair dryness with minimizing hair breakage by increasing elasticity of cortex of a hair.
For people who have a hair loss, taking daily dose of biotin may improve their hair growth.
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You should always try to obtain your daily dose of biotin from the diet and natural food.
If you want to take biotin to increase your hair growth the dose is much higher.
You should always consult your physician for a dose appropriate to you.
You will start seeing positive results after few months of usage (3-6 months and more).
Other Biotin benefits
Blood sugar balance
Because of biotin’s role in glucose production, it has an effect in the amount of sugar in the blood. The levels of biotin is indirectly proportional to the level of sugar; lower levels of biotin increases the level of blood sugar and higher level of biotin lowers or the level of blood sugar.
Biotin is one of the supplements recommended for treatments for people who have diabetes. Preliminary studies displays that a mixture of biotin and chromium can improve blood sugar control.
Biotin has been associated with aiding to fight and controlling diabetes, especially the diabetes type 2. Diets poor in biotin weaken the production of insulin, a principal hormone in the counterbalancing of blood sugar. Lately, examiners proved that insufficiency of biotin also influences the way insulin behaves on cells, providing a second basis that low biotin consumption conceivably creates issues.
Lack of biotin can also cause skin rash. This is because biotin is required to build healthy fats in the skin. These fats maintain the skin moist and flexible, and once biotin is not enough, the skin becomes flaky and chafed.
A biotin deficiency may also result a different skin problems like rashes, psoriasis, acne, overall itchiness, and dermatitis. Our skin needs to be nurtured not just from the outside but most importantly from the inside. Toxin inside the body forms throughout the nervous system and reveal itself on the surface of skin.
Aid weight loss
Biotin plays a crucial role in sustaining metabolic function and serves as a co-enzyme to aid break down food especially carbohydrates. The result is further accelerated when biotin is combined with chromium. Your inactive metabolic rate is raised and food breaks down quicker when consuming biotin.
However, research shows that there is no way the biotin can act as a weight loss pill. It is essential to pair the biotin supplement with a hearty diet and work out regime to make sure you achieve your slim-down goals.
Biotin processes almost every type of food that you ingest, including carbohydrates, protein, and fat. If the amount of biotin in your body is sufficient, the food that you take in will be processed more quickly, your sweat glands, nerve tissue, and bone marrow also work efficiently.
Biotin also shown to lower cholesterol, which when too high, can lead to heart disease like stroke and heart attack. Prior research has shown that biotin help reduce LDL or bad cholesterol levels. High doses of biotin with chromium helps reduced the level of triglyceride levels (fat).
Biotin is a kind of vitamins and it has an essential role in your body. If your body shows any manifestation of biotin deficiency, make sure to check with your health provider and consider taking biotin supplement. It will help you achieve and maintain good health in every part of your body.
According to the Linus Pauling Institute at Oregon State University, it is rare to have a Biotin insufficiency because, normally, intestinal bacteria form biotin in nimiety of the body’s daily needs. It is additionally obtainable in some foods.
All the same, an amount of metabolic disorders occur in person’s metabolism of biotin is aberrant, including inadequacy in the holocarboxylase synthetase catalyst which covalently binds biotin upon the carboxylase, wherein the biotin works as a cofactor.
Biotin is also crucial for standard embryonic growth, making it a vital nutrient during pregnancy and lactation. This is due to potential acceleration of biotin catabolism while pregnant. It can happen in people of any ancestry, gender, or age. The exceedingly low prevalence of biotin deficiency is possibly the result of a combination factors.
Possible causes of biotin deficiency include the following.
First, the daily requirement for biotin is very low.
Second, consuming or eating raw egg whites over a period of months to years. Avidin is an antimicrobial protein found in egg white that binds biotin and hinders its absorption. Cooking the egg white denatures avidin, making it susceptible to digestion.
Third, Genetic disorders such as Biotinidase deficiency, multiple carboxylase deficiency, and Holocarboxylase synthetase deficiency can also lead to inborn or late-onset forms of biotin deficiency.
Fourth, total parenteral nutrition without biotin supplementary.
Fifth, anticonsulvant therapy, or antiseizure medications, extended use of phenytoin, carbamazepine, and primidone can lead to biotin inadequacy but valproic acid therapy do not cause this condition.
Sixth, continued intake of oral antibiotics is also connected with biotin deficiency.
Biotin Deficiency Symptoms
Presently, there is no good laboratory test that can detect if you have biotin deficiency. The condition can only be detected by its symptoms. Below are some of the manifestations when one is experiencing deficiency in biotin:
- Fine and brittle hair
- Alopecia or hair loss
- Metabolic disorders
- Dry skin
- Fungal infection
- Mild depression
- Muscular pains or myalgias
- Hearing loss
- Brittle toe and fingernails
- Cradle cap
- Cracking corners of the mouth (cheilitis)
- Swolen and painful tongue
- Dry eyes
- Loss of apetite
Anyone can take biotin because it is considered as a supplement and not a drug or medicine and it can also be found in foods like, nuts ( almonds, peanuts, pecans, and walnuts), soybeans, mushrooms, pumpkin, sunflower seeds, root vegetables, cooked eggs particularly the egg yolk, sardines, other legumes ( beans, blackeye peas); whole grains, brewer’s yeast, cauliflower, and bananas.
Dean Burk - biochemist who co-discovered biotin.
Meat and milk can also contribute a chunk of biotin requirement. However, always consider the kind of preparation of foods because soaking and boiling can lose about 10% of the biotin during preparation.
Canning on the other hand is a lot challenging on the nutrient, leading to lose of about 40% to 80% of the original biotin. The great way to prepare a biotin-rich food, to keep the biotin content, is by steaming.
Let me share with you the World’s Healthiest Foods rich in biotin:
- Peanuts- 88%
- Almonds- 49%
- Sweet Potato- 29%
- Onions- 27%
- Oats- 26%
- Carrots- 20%
- Walnuts- 19%
- Salmon- 15%
How much Biotin you should take
Biotin is obtainable in multivitamins and B-vitamin complex supplements. It is available in the market in 10mcg, 50mcg, and 100mcg tablets. In 1998, the Food and Nutrition Board of the National Academy of Sciences determined a set of age-specific Adequate Intake or AI levels for biotin. These are the following:
- 0-6 months: 5mcg
- 6-12 months: 6mcg
- 1-3 years old: 8mcg
- 4-8 years old: 12mcg
- 9-13 years old: 20mcg
- 14-18 years old: 25mcg
- 19 years old and older: 30mcg
- Pregnant women: 30mcg
- Lactating women: 35mcg
There is no standard Tolerable Upper Intake Level or UL for biotin. Provided that biotin is given several thousand times the AI has been applied in medical settings, we attest that it is very unlikely that dietary biotin exhibits any health-hazard, even in the unusual conditions. Biotin is safe and well-tolerated. However, if you have any medical conditions or if you are pregnant or lactating, it is best to check with you doctor before taking biotin supplements.
Do not let a child take a biotin unless a pediatrician recommends it. If you are taking any kind of drugs or medication in a regular basis, consult with your health provider before you begin using biotin supplements because biotin may diminish or weaken the effect of particular medications.
On the other hand, some drugs do lower the biotin levels, along with some antibiotics, epilepsy drugs, lipoic acid, raw egg whites and these can increase the need of biotin intake. But again, make sure to discuss it with you doctor first to get the necessary prescription.
The biotin has never been reported to have toxins from food in any human nor animal. Also, the National Academy of Sciences was unable to find any proof for biotin toxicity, even if the doses reaching up to ten thousand times the adequate intake level advice.
The appropriate amount of biotin relies on several factors such as the age, health, present medications, and several other conditions. Bear in mind that products that are natural are not constantly safe and dosages can be very vital. Be sure to seek advice from your pharmacist, physician or other healthcare professional before using a biotin supplement!